The police said that Shakita Kaulesar-Ramsaroep drank a brew of weed killer and pills on Wednesday afternoon in Welgedacht, a residential area south of Paramaribo.
She also gave her daughters some of the deadly cocktail to drink. They were all rushed to the hospital where Kaulesar-Ramsaroep died on Thursday while the children, ages eight and two years, are reported to be in critical conditions.
In a statement Friday, the police said the woman may have been driven to suicide by some incident in her relationship.
They said her husband is overseas and it is not clear if he is residing abroad or on business.