In a high tempo encounter, the Sugar Boys got the better of the early exchanges but failed to capitalize on the opportunities presented to them.
In the second half St. Kitts and Nevis kept up the same momentum but shortly after, Trinidad and Tobago broke away with a counter attack in the 51st minute, when a shot from Kevin Carter beat Julani Archibald to give the visitors the lead.
Even after falling behind, the Sugar Boys still continued to create chances but failed to put one past the Trinidadian goalkeeper.
Local fans are hoping that the loss by the home team will not serve as a setback for their match against French Guiana on Sunday.
In the earlier game, Anguilla went down 4-1 to French Guiana helping the South Americans to bounce back following their defeat to Trinidad and Tobago on the opening night, Wednesday.
Trinidad and Tobago takes sole leadership of the group and remains favorites to win the tournament after defeating St. Kitts and Nevis.